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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTNNB1 All Species: 45.45
Human Site: Y654 Identified Species: 76.92
UniProt: P35222 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35222 NP_001091679.1 781 85497 Y654 R N E G V A T Y A A A V L F R
Chimpanzee Pan troglodytes XP_001137676 774 84747 Y647 R N E G V A T Y A A A V L F R
Rhesus Macaque Macaca mulatta XP_001115474 511 55731 R403 K P Q D Y K K R L S V E L T S
Dog Lupus familis XP_850439 744 81740 A627 I D A E G A S A P L M E L L H
Cat Felis silvestris
Mouse Mus musculus Q02248 781 85452 Y654 R N E G V A T Y A A A V L F R
Rat Rattus norvegicus Q9WU82 781 85436 Y654 R N E G V A T Y A A A V L F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516985 781 85506 Y654 R N E G V A T Y A A A V L F R
Chicken Gallus gallus NP_990412 781 85420 Y654 R N E G V A T Y A A A V L F R
Frog Xenopus laevis P26233 781 85431 Y654 R N E G V A T Y A A A V L F R
Zebra Danio Brachydanio rerio NP_571134 780 85502 Y653 R N E G V A T Y A A A V L F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18824 843 91134 Y667 R N E G V A T Y A A A V L F R
Honey Bee Apis mellifera XP_391947 811 88602 Y670 R N E G V A T Y A A A V L F R
Nematode Worm Caenorhab. elegans O44326 678 74493 P570 L Y Q L S K R P D G A R A V E
Sea Urchin Strong. purpuratus NP_001027543 825 89711 Y678 R N E G V A T Y A A A V L Y R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 65.4 66.4 N.A. 99.8 99.7 N.A. 99.7 99.3 97.4 97.1 N.A. 65.7 67.6 28.5 67.2
Protein Similarity: 100 99 65.4 77.4 N.A. 99.8 99.7 N.A. 99.8 99.6 99 98.9 N.A. 77.2 80.1 46.4 77.7
P-Site Identity: 100 100 6.6 13.3 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 6.6 93.3
P-Site Similarity: 100 100 26.6 26.6 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 13.3 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 86 0 8 79 79 86 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 8 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 79 8 0 0 0 0 0 0 0 15 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 72 0 % F
% Gly: 0 0 0 79 8 0 0 0 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 15 8 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 8 0 0 0 0 8 8 0 0 93 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 79 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 0 0 0 0 8 8 0 0 0 0 0 0 % P
% Gln: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 79 0 0 0 0 0 8 8 0 0 0 8 0 0 79 % R
% Ser: 0 0 0 0 8 0 8 0 0 8 0 0 0 0 8 % S
% Thr: 0 0 0 0 0 0 79 0 0 0 0 0 0 8 0 % T
% Val: 0 0 0 0 79 0 0 0 0 0 8 79 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 79 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _